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The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … people think of this as the targets of penicillin, so very important in that peptidoglycan cross-linking. These enzymes …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … Which ones are the most thermally stable? And those are important to us before we ask those next questions of will … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … young, but he’s been dead center and a lot of the really important recent events in data analysis and secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … are used in cell-cell communication. It’s really, really important part of their ecology, are these cells …

… … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… of a bonus episode, since I’m off schedule, but this is an important one that wanted to get out there as soon as … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… the energy and enthusiasm of young researchers, so it’s important to me to tell their stories too. If you have one … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … metabolites arose in evolution? DAN: Yeah, I think the important driver is to imagine if — let’s say you knew you …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … go into another country and take soil and discover a new important drug from the microbes in that soil, there are now … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… unique and different from one another. They are incredibly important to medicine, the environment, and human health. As … metabolism research, “Natural Prodcast” serves as an important line of communication to the scientific community. …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … Initially, my group really focused on marine actinobacteria. Then we moved into marine proteobacteria. Not a …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …