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… Corps, I decided I wanted to go into international agriculture. I had really changed my mind. I was thinking of … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … with human health and increasing our longevity and agriculture. And there’s so many applications. So it was really … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… it was good. DAN:  Yeah, I think you brought some of that culture too, to the Townsend lab, too, when you got there, … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… specimens collected and fungi isolated are preserved in the Culture Collection of Fungi from Extreme Environment, the …

… hadn’t explored before. Like, you know, maybe it’s a new culture of a new bacteria that you pulled from the soil, … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… at JGI. We love to work with single organisms and mixed cultures of fungi, algae, protists, bacteria, archaea, … of single species of bacteria/algae/fungi, or is mixed culture (polyculture) also considered? …

… genomics and multi-omics by working with research labs and culture collections to produce hundreds of diverse algal … and algae provide sustainable solutions for energy, agriculture, and the environment. … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an …

… comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … 2,000, 3,000 meters below sea level. And we’ve managed to culture, and in the lab, some rare actinomycetes. So by … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …