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… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening since 2005. … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … , which is St John’s wort and flower, which grows abundantly in the wild there. Cover it in oil. Most cases …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … danicum gen. nov., sp. nov. in the ubiquitous bacterial phylum Patescibacteriota phyl. nov .”  ISME …

… Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … and tens of thousands of members of these classes. And yet, there is no central open repository, which contains all … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … if you’re a grad student, if you don’t have a track record yet, you need to build a team around this project, right? So … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … that may have been missed by companies like Pfizer or Wyeth or that because they probably weren’t isolating …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really happened yet. It was unpublished at that point. But people would push … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly … in data policy. Data from projects for which JGI has not yet received samples as of Sep 30, 2021 are subject to a …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … Initially, my group really focused on marine actinobacteria. Then we moved into marine proteobacteria. Not a …

… in Nature and Medicine.” It’s obviously focused more on the bacterial side of the field, and it’s a little hard to find … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …