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… has recognized how important natural products are to understanding the natural environment, and so our Director, … gene clusters and to do research to get a better understanding of that data. ALISON: Awesome. So tell me why … and doing things that are useful to us or harmful to us and understanding all of that I think is what really drives me …

… to support BER's mission of achieving a predictive understanding of complex biological, earth, and … innovations for bioenergy and bioproduction, enhance understanding of natural environmental processes relevant to … The BER  major objectives are to: Advance fundamental understanding of genome biology and develop the genome-scale …

Complex libraries Multiple variants of sgRNA or a small coding gene assembled together in various combinations and … Text file of SNPs (incl location in genome, coding/vs non, syn vs non-syn aa change etc) and structural rearrangements, …

… and you can really see there is a gene cluster, or there’s none anymore. So this evolution of really when you don’t … actually can learn just by really digging into the data and understanding what’s going on there. And now, that’s all I … links that they must be made in a certain way by these non-ribosomal peptide synthetases. Because they thought, at …

… to provide direct biochemical datasets to improve our understanding of microbial metabolism. Of particular interest is understanding the distributed and dynamic metabolite …

The more well-known secondary metabolism systems are the “Non-Ribosomal Peptide Synthetases” or NRPSs. These are … is not a peptide? ERIC:  So what we’ve been looking at is non-peptides, so very small molecules that have a chance of … And it’s structurally really varied. And so we thought by understanding that we could learn how to make peptides, …

… another class of enzymes that my lab loves to work with are non-heme enzymes, and we work with them in a couple of different flavors. So non-heme enzymes, it just means that they need iron. DAN … the protein. So we work with Rieske oxygenases that are non-heme iron-dependent enzymes and also another class, it’s …

… capture microbial and viral diversity, leading to a better understanding of microbial communities and ecosystem …

… that can help you through the submission process by better understanding the capabilities and resources available for …

… interested in this and have made tremendous advances in understanding how to harness the power of second metabolite … in An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria Check out the agenda for the JGI’s 2021 …

JGI’s DNA synthesis and ‘omics capabilities to enhance understanding of gene and genome function, particularly …