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… be proposing a larger project that requires the work of two or more DOE user science facilities. That’s kind of out … of the topics we cover. OK. Long intro today. We’ll have two discussions. First up is Tanja Woyke , JGI’s Deputy of … our eukaryotic genomes, all our eukaryotic genomes. Fungal plant, algal genomes, a lot of effort goes into generating …

… ag[riculture] and I really liked – I became interested in plant disease in part because of what happened in my Peace … that got me into natural products to be truthful. So, well, two things. My PhD work was with a fungal pathogen called … So it’s maybe the culture. I’m a faculty member in two departments at [the University of Wisconsin-Madison] UW. …

… to do an independent study on ethnobotany of some of the plants that people were using for medicines in this very … intriguing. The squid – the Hawaiian bobtail squid has two organs that solely house– whose sole function is to … the glaciers and had this custom drill made to drill about two feet of glacier core that we field sterilized and …

… chemicals that are coming out of organisms, whether it be a plant or from the bottom of the ocean, from a sponge, or a … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola … special was like, you know, at that time, there are only two sequenced genomes of a Streptomyces , or gram-positive …

… To provide broad plant genomic capabilities, the DOE Joint Genome Institute … Institute for Biotechnology, which specializes in genome improvement for plants. As part of that partnership, the JGI … resource. To demonstrate that, we included datasets from two species, one of which is sweet sorghum Rio from a JGI …

… Uncovering associations between plant roots and fungi that can help or harm plant host health. The Science Researchers compared the … colonize Arabidopsis thaliana roots with genomes from other plant-associated fungi. Their analysis identified fungal … Programme: Deconstruction and Reconstruction of the Plant Microbiota (SPP DECRyPT 2125)’ and the Cluster of …

… scientific audience whereas now I’m sitting here with two people who know way more about natural products than I … so that’s weird, because it’s a bastardized version of the two because we’ll say methyl so we call them methylotrophs [ … DAN: Almost like you know that there is. AARON PURI: It’s a planted question Dan. Yeah. So overall I think what we’re …

… As a host, and a little bit of my newer work is focused on plants, but in both cases, you know, these molecules are how … sending signals. But really unpacking that complicated network of chemistry and communication is what I’m really … are … surrounding Tiny Earth is to create a course and a network of people to crowd-source antibiotic discovery. So …

… of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With advanced mass … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … to gain insights into how small molecules function within plants, microbes, and ecosystems. Identifying and analyzing …

… in order to challenge or kill off competition, right? And plants do the same sorts of things. And then, bacteria often live in symbiosis with plants and might actually be producing molecules that are … lots of stuff. On average, we had something– I think we had two biosynthetic clusters per MAG, which is pretty good …

… so they’re secondary metabolite peptides. And there are two ways that nature does this. The more well-known … being a chemist, and it’s actually quite hard to put those two things together. And natural products is one of those … transcriptomics, metabolomics, and natural products in plants, fungi, and microorganisms. If you want to …

… welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. … not know what I was doing. BRIAN BACHMANN: Yeah, that makes two of us. DAN UDWARY: So the audio quality was terrible. … We can also genetically manipulate them. We can do strain improvements. We can do all sorts of things. So that’s just …