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Every year, the JGI sequences around 35,000 samples — from plants, algae, bacteria, archaea, fungi, … around the world. Most of those researchers send their samples in from afar, without ever hearing much about the … So today, Chris Daum walks through the JGI’s sequencing pipeline, where there are freezers with names — but not …

… and culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. … and other natural product libraries, so not relying on single crystal X-ray diffraction, but looking actually at …

… we want a chemist to study the ocean. And I didn’t find a single job advertisement. But one day, I decided to really … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, … are many others, including Streptomycetes, which are common soil bacteria. DAN UDWARY: Yeah, we talk about them a lot …

… predict or just understand better the language of microbial cell-cell communication. And he told us about his work in … it! So, that’s this episode. I still have more stuff in the pipeline, including another recording made at SIMB, and any … and they were able to synthesize the genes for every single one of those and put them in individual plasmids and …

… the Letter of Intent; rather proposals are submitted in a single step. … The researcher then submits a proposal for …

… or online catalog, I guess. So we've also been able to get soils from Purdue campus itself and been able to actually … So chemicals are their way of talking. You bring up an excellent point though, and I think this is an area that is a … been shown today is it's more a quorum sensing within a single species. DAN: Within a species. Genus? BETSY …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based … of bioenergy importance. … We are using cutting-edge single-cell profiling methods, including single-cell …

… great conversations that we’ve already recorded with some excellent scientists, and that’s probably how we’ll continue … is a chemical compound called geosmin that’s produced by soil bacteria that live all over the place. So that smell of … they figured out that they could culture the plant cells and produce enough that way in really large like 7500 …

… a new culture of a new bacteria that you pulled from the soil, maybe it’s, you know, we talked about sponges, go pull … be successful. Right? Because we don’t – drugs are usually single molecules, they are not extracts. And so yeah, in … in ourselves and every living thing that we know of with cells, and so… So you can think of DNA as maybe being …

… of Work (project roadmap) Users must prepare Materials (Samples) for Submission before they can receive an emailed Approval to Ship Samples that will be subject to the DOE JGI’s capabilities …

… advantages for farmers concerned with improving sustainable soil management practices. … In June 2020, the Department of … genome engineering (CRAGE), which offers single-step genomic integration and prototyping of complex …