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… some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really cool. And … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 …

… looked across many organisms to see that aminotransferase enzymes have evolved mix-and-match characteristics — … to the way many organisms function, they have a sense of why nitrogen metabolisms can be so varied.  As evolution has … different Swiss Army knives — explaining a bit more about why and how nitrogen metabolism is so robust and varied.  …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in … The Metagenome Program focuses on the high-throughput sequencing of microbial communities to uncover the complex … Exploration of phylogenomic novelty: Advances in metagenomic sequencing, assembly and binning have enabled reconstruction …

… – problems that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … the JGI. And so now here at the JGI, I work with all of the sequencing data that the JGI produces to try to find and …

… For sequencing projects, once work is under way, raw sequence … More on Sequencing Projects …

… by generating data in three overarching categories: DNA Sequencing , DNA Synthesis and Metabolomics .  Many users …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … it interacting with, like, a binding pocket for one of the enzymes, so something that’s metal dependent? Is it– and we … really exciting work on figuring out how to get genomic sequencing data for the fungus garden because it’s more …

… Science program. It used to actually stand for Community Sequencing Program. Also CSP, same acronym. But as JGI, as a … facility, evolved, and as we started to do more than just sequencing, we thought the name community sequencing program … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore … The Microbial Program focuses on using advanced sequencing technologies to explore microbial diversity — … datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … 20S proteasome. The proteasome in the cell is a bundle of enzymes that is used to degrade proteins, peptides, that are …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … cool. The vanadium haloperoxidases are some really cool enzymes, and it was fun to see that project take shape. … to grow. If you hear Nigel talk, he is very interested in sequencing a lot more natural product-heavy culture …

… Genome to Enzymes and Pathways focuses on discovering and characterizing enzymes and pathways vital to DOE missions. Using … biosynthesis, synthesizing and biochemically analyzing enzymes to support mission-driven research. Rapid Metabolic …