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… out every two weeks. This time, we’ve got a great interview with Ben Shen, from the Scripps Research Institute in … there. So, check out the show notes, and I’ll put up some structures and link to some resources you can use to get … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that …

… to tap into the largely unexplored biochemical diversity within secondary metabolites, expanding their potential … plants. These compounds are key to organisms' interactions with their environments and with each other, from defending against predators to aiding …

… program seeks research proposals that integrate genomics with nanoscale science, accelerating discoveries and … All JGI data is made publicly available in accordance with the JGI’s Data Policy . In cases where the JGI provides customized analysis, the JGI also participates in publication of results. Go here for additionial information, …

… get to say that six of those are based on natural product structures.  DAN: One of the things that keeps me awake at … drug discovery train moving, drug companies started working with some techniques referred to as “combinatorial … lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there …

… because I really enjoyed the review that you wrote with Marnix on putting that stuff together. It’s been kind … their ability to evolve, to go with horizontal gene transfer and run with it and produce different chemistry. … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… we’re going to be presenting some conversations we had with scientists in the field of natural products. So, it’s a … they’re complex, they have different tissues, different structures, different spores. I like looking at that I’m a … this one could be really good because, hey, it had a methyltransferase that changed. And, you know, I wish we could …

… pathways. And today, we get to present our conversation with Marnix Medema , from Wageningen University in the … cluster database, and a tool for predicting natural product structures from genomes. And I was writing grants furiously … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

… We offer internship opportunities through working directly with specific universities, continuing education programs in the Bay Area, and established programs affiliated with the Berkeley Lab A-LIFT team.    Overall, our aim is to … JGI-UC Merced internship program, a similar collaboration with AAMU was launched in 2024.  …

… episode 12 of Natural Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in … Like me, she’s a genome miner and has been involved with the AntiSMASH and MIBiG projects. And I found her … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… 8 of Natural Prodcast. This week, we have our conversation with Professor Eric Schmidt, from the University of Utah. … and love the idea of working on harder organisms, with the kinds of challenges that usually lead to surprises … a protein using the normal cellular way of making proteins, with a ribosome. Then, some other enzymes chop the protein …