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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … toxic molecules, and that human beings know, today, for small molecules. So they’re in the picomolar range. ALISON: … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … a company, here in La Jolla, called Nereus Pharmaceuticals, small biotech. And that’s a whole other story, biotechs. But …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … FRANCISCO BARONA-GOMEZ: Exactly. And I have just written a small piece where we discuss the future of merging … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

The IMG group owns and maintains integral components of JGI’s production workflow, … data and serving them to users via the Integrated Microbial Genomes & Microbiomes (IMG/M) system. Research Team    … The …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … So we began to sequence that genome – it was a relatively small genome, about five and a half million base pairs. It …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient … realized under standard laboratory conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being …

Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of … Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned into …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … around countries. And I was actually in Croatia on a small island off the coast in the Adriatic Sea, and I … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… while, but Natural Prodcast is back again for another round of episodes. If you stick around for the next few months, … we don’t just sequence one microbe for you, we sequenced thousands for you or thousands metagenomes. And I think also … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

Below is a brief description of the process needed to prepare and ship samples for sequencing by the JGI.  Additionally it includes instructions on … Sample QC Protocol JGI’s Total RNA Sample QC Protocol JGI’s Small RNA Sample QC Protocol DNA Extraction 101 : tips, …

… schedule. This should be coming out on the first Thursday of the month, just like I promised. Now I just have to make … coelicolor versus Streptomyces lividans. They both have the genes. The genes are pretty much 100% identical. We don't … So cis versus trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did …