Search

… into functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for bioenergy, … develops data science tools for workflow management and novel automations for DNA design, assembly and analysis Overview of biodesign … sequence design for assembly by Gibson, Yeast recombination and Golden Gate methods …

… the high-quality data we generate, tools like artificial intelligence can empower the global research community.   We have two key priorities:  The JGI is involved in efforts to integrate data in support of new research questions that span domains. We also work with our partners to build …

… as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … niche in chemical enzymology. So, we talked about her JGI DNA synthesis project to explore the chemical capabilities … the products that they’re making. And you want to have good binding to your substrate and high turnovers. But if you …

… lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there … 80s and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – … proteins that produce secondary metabolites. Do you recognize this? DNA 🡺 RNA 🡺 Protein ALISON: This is central dogma. …

… and eukaryotes, and they range in particle and genome size from small, to large and even giant. The genomes of giant … giant viruses that belong to the nucleocytoplasmic large DNA viruses (NCLDV) supergroup. The expansion of the … researchers previously applied this approach to uncover a novel group of giant viruses dubbed “Klosneuviruses.” …

… The Synthetic Biology lab is divided into a DNA synthesis production group and a synthetic biology … with scaling the production of large, difficult to synthesize constructs such as those involving biosynthetic clusters, … applications.  We are interested in:  characterizing novel enzymatic activities using phylogenomic driven …

… chemistry, and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of their synthases so that we can start to use the DNA sequence to predict or just understand better the … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… that had remained largely unknown and underutilized by industry. When Director Nigel Mouncey joined the JGI … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, … to test hypotheses via designed and assembled physical DNA constructs that can then be functionally characterized.  …

… an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … said, if these are bioactive, why couldn’t they be utilized as drugs? If they have an impact on another organism, … We now have cell pellets. And we’re pulling genomic DNA out of those cell pellets. So, we’re about ready to send …

… and then I switched to chemical engineering and realizing that wasn’t for me and eventually, I got to chemistry. … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … We find chemistry that’s known, or sometimes novel, but often known, and yet the clusters don’t look the …

… bacterial cells, visible to the naked eye. The unusual size is notable because bacteria aren’t usually visible … along with its life cycle. For most bacteria, their DNA floats freely within the cytoplasm of their cells. This … in more details. These techniques allowed him to observe novel, membrane-bound compartments that contain DNA …

… Kerrie Barry or Vivian Ng Prokaryotic projects: Tijana Glavina del Rio , Danielle Graham , or Miranda Harmon-Smith DNA Synthesis projects: Miranda Harmon-Smith Metabolomics … You can visit the Products & Offerings section of our website for more details, including a downloadable pdf of products categorized by Science Program.  …