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Mining Metagenomes for Cas Proteins
… Cas14 proteins discovered from JGI’s IMG/M database and … Institute.  The Science Researchers report the discovery of miniature Clustered Regularly Interspaced Short … Integrated Microbial Genomes and Microbiomes (IMG/M) suite of tools managed by the U.S. Department of Energy (DOE) …
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Metabolomics Program
… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems at the … fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy and nutrient …
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Natural Prodcast Episode 8: Eric Schmidt
… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the science and scientists of secondary metabolism.  DAN: Hey there and welcome back … on this: Most of the machinery in any living organism are proteins, which are made up of chains of amino acids. …
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Natural Prodcast Episode 19: Bill Fenical
… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … early on. So here we go. So maybe we start with what’s your origin story in natural products? How did you get started in … that improve their survival. Those molecules, over evolutionary time, become targeted to certain biological …
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On the origin and evolutionary consequences of gene body DNA methylation
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How to Submit Sequencing Samples
… Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … step for many projects at the JGI. The quality of the starting material is one of the greatest predictors …
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Natural Prodcast Episode 22: Alison Narayan
… Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … did it all begin? DAN UDWARY: Yeah, I love to hear people’s origin stories. ALISON NARAYAN: For me, the initial … it’s been a long time since I’ve actually isolated some proteins off the bench. I am well aware of the pitfalls of …
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Doubling Down on Known Protein Families
… online Oct. 11, 2023 in  Nature highlights the vast array of functional diversity of microbes through a novel approach … Fleming. “This was a massive analysis of 1.3 billion proteins with massively parallel computations.”  Guided by … isn’t much scientists can tell about its function or its origin. As a result, these genes were typically discarded …
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JGI@25
… Celebrating 25 years of genomics research 2022 marked the JGI’s 25th anniversary. We revisited a number of notable achievements that showcase our collaborations and … the JGI’s 25th anniversary, the JGI mural references dozens of iconic JGI contributions to advancing the frontiers of …
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Olpidium, The Key to the Origin of Terrestrial Fungi
… Before 2006, Olpidium was one of the many obscure fungi of Chytridiomycota (the … attracted the attention of many mycologists with the two publications of the kingdom-wide, multi-gene phylogeny of … turned out to be a mixture of genetic material with various origins, ranging from fungi, plants to bacteria. Back in …
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Tracking the Origins of Methane-Producing Microbes
… archaea are estimated to produce 500 million tons of methane a year, which is over half the total global methane production. They are thought to use billions of tons of the carbon dioxide trapped in biomass each year … “This provided us with genetic evidence to tie together the evolutionary history of the different types of …
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Patterns of genomic variation reveal a single evolutionary origin of the wild allotetraploid Mimulus sookensis
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