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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … that background, well, everybody starts somewhere right? Most of what you need to know is a Google search away! If … I have been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a …

… the DNA that was breaking the sequencing from really being functional was these secondary metabolite pathways. So why … that they’re making in terms of stewardship. Now, that’s mostly talking about antibiotics in the clinics of for human … something like soil, which I’m working on now, this is a complete black box, we’re talking many, many orders of …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. …

… for researchers to request the capabilities and expertise of both national user facilities in one research proposal.  … challenges in the sourcing, recovery, and utilization of critical minerals and materials. The proposal submission … like expression constructs or sgRNA libraries to the user. Most users of the Molecular Foundry work side-by-side with …

… well-integrated across JGI departments to ensure a robust offering of sequencing capabilities and products to our users. This … the JGI’s focus on expanding molecular capabilities and functional genomics, scaling capacity through end-to-end … An assay used for profiling transcription factor binding sites across entire …

… schedule. This should be coming out on the first Thursday of the month, just like I promised. Now I just have to make … really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m really happy today to be handing over … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the biological … into practical applications, including sustainable biofuels, biomaterials, natural products, and environmental …

… — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … Agreement and Appendix. An Appendix identifies the type of work or specific proposal to be covered under the …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … drive innovations that could advance our understanding of Earth’s ecosystems. … offering new approaches to address some of the world’s most pressing challenges. …

… Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … step for many projects at the JGI. The quality of the starting material is one of the greatest predictors …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … really excited today. We have, by far, I think, one of the most decorated and legendary natural products people– he’s … know, I’m here to find a job. I would like to do something completely new. And that is to begin to study the organic …

… using these probes to look at host pathogen interactions mostly with like enteric bacteria. And I really fell in love with the bacteria part of that. And so I decided to completely change gears and go and do a postdoc with a woman … that people work with are actually alpha or gammaproteobacteria. They just have this very restricted niche. …