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… also dying to talk in more detail about the JGI Secondary Metabolism Collaboratory , which is the big huge monster … of thought with that. So some people are interested in cave microbial– people are interested in the more extreme … from actinobacteria now. And we’re focusing much of our efforts on myxobacteria. And they’re also replete in caves, …

… products and the science and scientists of secondary metabolism. Hey there, and welcome back to Natural Prodcast, … genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial …

… all of these programs can and often do involve secondary metabolism. JGI’s mission is broadly focused on biological … the user programs at the JGI, and I’m also the head of the microbial genome program. And I’m a scientist here. And have … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual CSP …

… a podcast about the science and scientists of secondary metabolism.  DAN: Hi again, and welcome to Episode 6 of … things in microbiology and biology in general. And her efforts first at Yale and now at University of Wisconsin and … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And …

… a podcast about the science and scientists of secondary metabolism.  DAN: Hey there. This is Dan again, and you’re … the history of the field of natural products or secondary metabolism, depending on which term you prefer. In this … point that you could understand the genetics of secondary metabolism, it became possible to do something that the …

… Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic … provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence, in … with functional annotation, taxonomic classification, and microbial host predictions.  …

… I got him on to talk about JGI’s vision for secondary metabolism, his past in industry in developing natural … I did my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for … week. We started doing a whole bunch of strain engineering efforts. We did a lot of fermentation. We had a really …

… chairs and I talk about SMC – which is the new Secondary Metabolism Collaboratory data portal I’ve been working on … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called … and they used that on all of IMG’s genomes. But IMG is microbial genomes — mostly bacteria and archaea. And we knew …

… Applications group explores the genetic makeup of natural microbial communities using a variety of cutting-edge … To provide additional functional insights into microbial genomes, the JGI now uses laser microdissection to selectively isolate and sequence microbial aggregates after first imaging with various …

… physical separation of a biologically relevant unit from a microbial community, such as a microcolony, microbial aggregate, or a specific subset of free-living … sample, annotation ( IMG/M ), binning Depends on project Microbial Minimal Draft, Isolate Draft quality microbial …

… crops, enhance biomass conversion efficiency, and discover microbial pathways for producing biofuels, biochemicals, and … Critical Minerals and Materials (CMM): Genomic studies of microbial and plant metabolism reveal biological routes to recover, reuse, and …

… for DNA and RNA extractions to support plant and other efforts. The JGI works closely with DOE computational …