Search

… want to say thank you, personally, to everyone involved in making this happen. We had a really fun conversation with … Oceanography]. ROGER:  Yeah, that’s right. We were postdocs together in the mid 2000s, I guess. You were working for … might be more to be gained than just subject matter, by making that change. So I went to the University of British …

… excited. This is the first time we’ve recorded something together. So, this is fun. MENAKA WILHELM: Yeah, it’s true. … And so I don’t know. I thought it’d be fun for us to work together to talk about this kind of stuff and talk to a few … team up with somebody who can do that. And then the team together makes a really strong proposal and a strong …

… new company called Corteva, bringing these two businesses together. And so I’d reached this time when I thought, well, … we’re doing, single cell work we’re doing. And using these together along with all of our computational tools to really … And so I think this is really cool technology now that is making up a lot of our expression platform work. And I think …

… heard a little about these, and Aaron and JGI are working together to try to understand the enzymology of their … the anaerobic ecosystem. And you have some oxygen that is making its way down. And in that Goldilocks zone is where … behaviors. And so immediately you know like I said, we’re making all of these hypotheses or you’re fantasizing about …

… dogs actually, one should think of, they’re always paired together. And maybe they’re not always – some like them, … if you looked at the statins, you might find many fungi are making similar looking statins. But, this one could be … you can get sort of an idea from synteny how to place it together. So this is really just an effort to close those …

… And so, I was working on chemically synthesizing and making derivatives of this to test its anticancer agent … cluster and a gene cluster for natural product might be all together. And so that's how we decide what we're going to … this journey, is finding these enzymes that are capable of making those strange ring systems. JACKIE: Why? Is it just …

… most decorated and legendary natural products people– he’s making a face. Talking to us today is Bill Fenical from … I asked the simple question, are these plants and animals making chemical compounds in a way that’s similar or … settled there as well, as a faculty member. But we were all together. There was even a degree of, I would say, …

… I was like, no, I’m going to study architecture. I like making things and designing things. I’m going into … that when you know what kinds of products the genes are making, to be able to close any genome. So it sounds like a … still with us because I know we’d be having a lot of fun together. Alison  Yeah. Okay. That’s just what I was curious …

… of shared reactions that most living organisms share – have together. Obviously that is flawed, because it’s biology and … and accept new genes coming in and out. So, if you start making the chemistry of those organisms, then you could … are just at the stage in which synthetic biology could be making secondary metabolism more useful than before. With …

… I found an amazing editor. And yeah, it just kind of came together in the most delightful and unexpected way. So I had … are experts in virology and immunology and we’re putting together a grant right now to look at some of these in …

… you can smell it. That fresh dirt smell: that is bacteria making natural products  ALISON: Hmm. It kind of – it’s kind … fungi, you know everything. These are shared pathways for making amino acids and nucleic acids for DNA and breaking …