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… any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  However, … and/or synthesis effort at the JGI. There is no cost to the user and no granting of funds. … confidential. Once a project is selected, however, we will post the PIs’ names and the proposal titles. All data will be …

… under standard laboratory conditions by their native hosts. We are developing cell-free based systems to express … toolkit (HERC-tk) to enable users to identify the best host to express their BGC(s). This is based on extensive … JGI researcher Dan Udwary hosts this “fireside chat”-style podcast about natural …

… even know of your existence back then. So there was no hostilities. Dan Udwary: That is certain, yes. So welcome. I … still under development. That you guys are – Kai probably most, right? – is you guys are still adding to it and … encode the very small precursor peptides that end up being post-translationally modified into ribosomally synthesized …

… which ones express the best in E coli? Which ones are the most thermally stable? And those are important to us before … with. But I mean, we found sometimes enzymes that are the most similar within our libraries can have drastically … And so starting from some of the enzymes that we had the most data on and knew the most about, working with my …

… really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m really happy today to be handing over … in natural product biosynthesis. I then went on to do a postdoc with Bill Metcalf, also at the University of Illinois … great question. So we do a couple of different things. Most of them are actinobacteria. And so we get a lot of them …

… networks of relationships between microbes and their hosts. Our work reveals how these interactions shape … Studying microorganisms that thrive in Earth's most extreme environments: We study genomic innovation that allowed microbes to adapt to live in Earth's most extreme environments, from deep-sea oceanic fluids to …

… that city is where I first met Roger, when we were both postdocs at Scripps Institution of Oceanography. Roger was … of Oceanography]. ROGER:  Yeah, that’s right. We were postdocs together in the mid 2000s, I guess. You were working … discovery, predominantly in diseases of importance to each host country. It was built very much on the foundations of …

… Sure. So my lab has really converged on the study of host-microbe chemistry. And the interactions– As much as we … I ever can at the level that we’re working. And so we do host-microbe chemistry.  We’re interested in – like I can … to do it as an undergraduate and a graduate student then a postdoc and then a job.” Instead I got interested pretty …

… the future. So, then we were using these probes to look at host pathogen interactions mostly with like enteric bacteria. And I really fell in love … so I decided to completely change gears and go and do a postdoc with a woman named Mary Lidstrom at the University of …

… senior scientist, about the project. The story is reposted here in modified format; their conversation has been … started off with 12 plants, which are JGI Flagship Plants, mostly related to biofuels and feedstocks. And then we … of 40 percent of genes across Gene Atlas plants. Comparing orthologs among common gene sets between species allowed us …

… to tell you about in this introduction. First and foremost, our interview this week is with Professor Brian … to join me in mentally welcoming Natural Prodcast’s new co-host, another old friend of mine, Professor Jaclyn Winter , … of Utah. Jackie was a grad student while I was a postdoc at Brad Moore’s lab , went on to some cool …