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It was actually when I was traveling at the end of first year University. Quite a lot of people in Europe do this … like. I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. … It’s them that do it. They created the Wiki. They edit the pages. They add the content. They run the Twitter account. …

ALISON TAKEMURA: And this is Paul Jensen in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. ALISON … I mean, I am– yeah. I just got the position like three years, four years– four years ago I think. Yeah. Yeah, Paul … tools for natural product researchers that easily can identify secondary metabolite pathways in metagenomes, which is …

As part of the JGI’s 25th anniversary celebration, the 2022 Annual Meeting featured speakers who shared a look back … Lab. Like the mural, the JGI’s accomplishments over 25 years span a broad, colorful range. Behind every genomic …

… of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary metabolism … that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on …

Natural Products conference, which took place last January 2020 in San Diego. San Diego, of course, is the “home turf” … advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole …

… of this is based on a really great paper that came out in 2020 where this is all explained in detail, so if you’d like … the content produced by microbes the result of millions of years of evolution. And if we could actually link terms to … evolution is acting very strongly. There is very strong purifying selection, and what matters is a final product. So it …

I have been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise to … data that the JGI produces to try to find and identify natural product biosynthetic gene clusters and to do …

… company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t …

… then you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … me to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the …

… (VEGA)  …   The JGI is represented at conferences year round; find out where our researchers will be …