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… been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise to … data that the JGI produces to try to find and identify natural product biosynthetic gene clusters and to do … heard of the Salem Witch Trials back in the what? 15th, 16th century.  ALISON: Yeah, I lived in Massachusetts for a …

Foster and too many others to name at JGI for the last two years or so. SMC is now released and ready for the public to … about natural products. So in Brad’s lab, I worked on identifying and characterizing haloperoxidases from bacteria. And … you go to the website, which is smc.jgi.doe.gov , the stats page is showing me that right now we have just over a …

… of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary metabolism … that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve … microbiome field, many people had just been looking at like 16S taxonomic profiles of these communities looking at who …

… of the research that you’ve been doing the last couple of years. And I really want to make sure that we talk about … But thankfully that worked out. And I spent 30, 40 years diving all over the world and bringing samples into … course using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …

I mean, I am– yeah. I just got the position like three years, four years– four years ago I think. Yeah. Yeah, Paul … all these very, very related genomes, right – on their 16S level, they’re almost identical! But seeing all these … tools for natural product researchers that easily can identify secondary metabolite pathways in metagenomes, which is …

… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … we have here – all of them were collected before 2016, before that true enforcement of the Nagoya protocol. And … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t …

… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole … vehicles. Brad: You did not! Alison: I did, like 2016, I think. Yes, it was just so funny to hear how they’re …

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… was at the Broad Institute in Cambridge, Mass. for a couple years before joining Warp Drive. And what kind of pushed me … time. And yeah, I mean, that was let’s see, maybe 5,6,7 years ago, and I’ve – I haven’t looked back. ALISON: So you … to be involved in signaling. We’re not perfect at identifying what these pathways are yet. So there’s still a lot to …

… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very … how much blood, sweat, and tears went into trying to identify that you had the right cluster before you sent it out for …

… then you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … has evolved over, you know, probably – possibly billions of years. And so it is pretty used to the way that the assembly …

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