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… been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise to … data that the JGI produces to try to find and identify natural product biosynthetic gene clusters and to do … probably heard of the Salem Witch Trials back in the what? 15th, 16th century.  ALISON: Yeah, I lived in Massachusetts …

… has a book called The Plant Hunter and I’ve read all 400 pages of her life and I feel like I have a new friend that … And so a path opened itself to me, just before my senior year of college, a chance to go to the Amazon and work with … they were starting to show the ability to really identify, and get crystal structures out of these mixed powders, …

Developed in 2017, the PDT was established in part to help better-connect … with the JGI and Berkeley Lab Biosciences Area to quantify atmospheric gas mitigation properties of multiple rice …

… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t … at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole …

… (VEGA)  …   The JGI is represented at conferences year round; find out where our researchers will be …

… in the Peace Corps – I was there for about three and a half years – I worked at a high school. And one of the things … today who said “Oh, the ITS which we thought would identify to species”… he’s now found that some fungi have … Like, ironically, yeast, which has a small genome has 15 chromosomes. Where Aspergillus has eight chromosomes. It …

… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very … how much blood, sweat, and tears went into trying to identify that you had the right cluster before you sent it out for …

… was at the Broad Institute in Cambridge, Mass. for a couple years before joining Warp Drive. And what kind of pushed me … time. And yeah, I mean, that was let’s see, maybe 5,6,7 years ago, and I’ve – I haven’t looked back. ALISON: So you … to be involved in signaling. We’re not perfect at identifying what these pathways are yet. So there’s still a lot to …

… then you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … has evolved over, you know, probably – possibly billions of years. And so it is pretty used to the way that the assembly …

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