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… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very … they had the same conserved polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: …

… there. This is Dan again, and you’re about to listen to the 3rd and final part of Natural Prodcast’s “Primer” episodes. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … has evolved over, you know, probably – possibly billions of years. And so it is pretty used to the way that the assembly …

… that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve … time. So they had actually sequenced the genome a number of years earlier as one of the first Streptomyces genomes that … that I was exchanging with people. So I think I wrote 3,000 emails in the course of one and a half year while …

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… I mean, I am– yeah. I just got the position like three years, four years– four years ago I think. Yeah. Yeah, Paul Jensen. What … all these 120 genomes, and each of them have– I don’t know– 30 gene clusters or so. So I think I spent two years only …

… been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise to … professor at the University of Rhode Island for a couple of years before I left that to join a biotech startup. And … about that.  DAN: Yeah, you know it took several hundred years for us to even understand that it was maybe natural …

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… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … AARON PURI: Sure. Great. I have a job for a couple of years. But the other thing that we can do that we’ve been …