Search

… on microbiomes they only talk about the bacteria. My god! 30% of our gut microbes are fungi. It’s really frustrating … And because the average fungal genome, I don’t know, is 30 megabases? Basidiomyetes might get to 50. Some of them go … there – some are private – that, you know, maybe you have 300 contigs. And so most fungi… Oh, the fungi vary in number …

… resistance genes, it may not be better than something that already exists. And the hit rate on if you have a target gene … and against primary cells isolated from patients up to 12 markers at a time. And these are phenotypic markers. So … anybody in natural product discovery in any field and even 30 years ago would say it’s the [key to] success. And that …

… internship partnership that started in the summer of 2014. …

… analyses and metabolomics. At the same time, the team is expanding current capabilities in strain engineering and …

… So it’s there and doing things. ALISON: Right. Yeah. DAN: Alright, so a subset of proteins are enzymes. Enzymes are … is also duplicated itself. And so there’s, you know, we’ve already said secondary metabolism is everywhere. But it turns … your cultures, but then you’re going to find another 20 or 30 secondary metabolism pathways that you didn’t even know …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… available datasets encompassing >150,000 isolate genomes, 230,000 metagenome-assembled genomes (MAGs), and 40,000+ … Draft Genome Sequence of Trichococcus flocculiformis DSM 2094T Isolated from Bulking Sludge in Germany. Microbiol … DSM 14810 (JK 615T) and Butyrivibrio fibrisolvens DSM 3071 (D1T). Microbiol Resour Announc. 2024 0:e00517-24. …

… have no extra genes hanging around, they still dedicate 20-30% of their genome to secondary metabolism. So it’s very … an international ambassador? MARC: Yeah, I believe it was 2012 when she started this at Yale, and she only had six … So, lots of samples. ALISON: Yeah, how many samples have already come through? MARC: I’m the wrong person to ask on …

… I worked on the aflatoxin project together, which – we’ve already talked a little bit about aflatoxin in some other … were really good chemists and biochemists and biologists already working on various sub-classes, but they weren’t … be a lot better at rationally making compounds.  DAN:  Alright, that sounds really cool.  ERIC:  It is really cool. …