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… or a seaweed, were just having just remarkable chemical structures and things that people hadn’t seen. For every … chemical”. And they found one, and they solved a chemical structure. But they, too, struggled with whether there were … in size, they then quickly were able to then solve the structure. And when they solved that structure, that quickly …

… Yeah. DAN: Yeah. So that involves figuring out the structure of that pure molecule. And that can that can take … get to say that six of those are based on natural product structures.  DAN: One of the things that keeps me awake at … proteins are actually molecules too, right? And so in a biological context, natural products and primary metabolites …

… come at it from many different directions. And if somebody brings some new approach or some new way of thinking or … anaerobic ecosystems. But these are actually– so methane– biologically produced methane is produced from degradation … “tail of the acyl homoserine lactone” can have different structures, and that is akin to what you’re referring to …

… there are now international regulations that provide a structure for ensuring that the countries that are the … convention I’m talking about is called the Convention on Biological Diversity . And there’s something called the … it be the Western person comes in and takes the plants and brings them back to their lab. I think that’s my overall …

… working with him for several years now on the chemistry and biological activity. So the chemistry and function really of … your opinion then on bioprospecting in sparse nutrient environments versus the tropics? Because like you say there … spectrometry on this massive scale.  And of course, that brings about massive problems just as much as it brings …

… depending on what kinds of plants, and what kinds of environments, they live in. But it turns out, they have a … from polyketides. At least I mean, I haven’t looked at the structures and details for a long time. But… DAN: Yeah, …

… scientists who do the work to understand all of the amazing biological chemistry in nature! In this introductory …

… there. So we’re looking at how they adapt to these extreme environments. And then can we use that, for example, like … Everything that we’re finding seems to be a new structure, and the microorganisms are novel. I mean, we have … a flag, maybe, but also gets other people’s attention and brings more people into a problem or whatever– or helps …

… that you need to do these coordination bonds, then many structures will be able to work. So, for example, in that … of relationship between the natural forces, the chemical structure that is derived from those natural, evolutionary … from nature without paying attention to the evolutionary biological relationships from which they were taken away. …

… everybody else started looking at things and doing chemical structures, learning a little bit about things. And that was … over evolutionary time, become targeted to certain biological systems in the target organism. So, if you want … chemical compounds, again, that were different, different structure types. We started amassing a collection of marine …

… cluster database, and a tool for predicting natural product structures from genomes. And I was writing grants furiously … a nice video. Alison Takemura: Marnix, It’s just from the biological perspective, like what was this bacterium, and … for the attention of the community. Dan Udwary: Well, that brings us full circle back to my introduction. So maybe …

… and to help them translate genomic information into biological function.  The emphasis is on projects leveraging …