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… question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked … before– or kind of around about when the first genome sequencing was done. But natural products– marine natural … Dan Udwary: Yeah. Kate Duncan: So they’re also incredibly adaptable. I think there has been some examples of real …

PIs who drafted them.  … Elucidating Sphagnum microbiome genetic interactions for improved growth at elevated temperatures … Adaptive strategies in a cosmopolitan and abundant soil bacterium: genetic microdiversity or core metabolic flexibility? … …

… capture microbial and viral diversity, leading to a better understanding of microbial communities and ecosystem … Ladau, J. et al. (2019)  Spatial, Temporal, and Phylogenetic Scales of Microbial Ecology . Trends Microbiol. …

… partnerships in developing countries for research into various aspects of biodiversity, of which natural … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire … in lots of areas, we would like to do a better job of understanding gas phase reaction mechanisms. We would like …

… marine natural products chemist, Richard Moore, and get into seaweed, robots, algae, and biocatalysis — and he makes … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … in a laboratory. And so, for us, we’re fascinated by understanding the logic of nature and how it can control …

So maybe we could start with that background – what got you into secondary metabolism, besides being forced to work with … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … for many millions, sometimes billions, of years. And understanding how those changes that evolution brokers are …

… more students to enter the STEM workforce by fostering an understanding of our role in advancing the energy and … at UC Berkeley is a program designed to foster a profound understanding of research methodologies within the realm of …

… and you can still make more of it, then you start going into human trials or animal trials first, and going through … and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … in terms of – well it’s really simple in terms of understanding it because it’s an assembly line. You just go …

I think for Natural Prodcast, I think the question that generally comes up that people come to me asking like is– … Science program. It used to actually stand for Community Sequencing Program. Also CSP, same acronym. But as JGI, as a … genomes. Fungal plant, algal genomes, a lot of effort goes into generating these data sets. There’s a lot of manual …

… other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … discoveries and catalyzing a major transition of biology into data science.  Research in the Kyrpides group focuses … Kyrpides NC. et al. (2016) Microbiome Data Science: Understanding Our Microbial Planet. Trends Microbiol. …

… of Energy.   The JGI provides integrated high-throughput sequencing, DNA design and synthesis, metabolomics and … to support BER's mission of achieving a predictive understanding of complex biological, earth, and … strains, or enzymes to convert plant biomass components into fuels, chemicals, and bioproducts, or to control …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … We then investigate the coding potential to find novel functions that may impact microbiome structure and …