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… So we started out internally by making a list on the whiteboard of the top 50 journals that we thought were most … could then show that to collaborators and say, “This is a prototype. If you will help, we could do this in a more … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … symbiont, a microbe, that produces antibiotic chemistry to protect the crop that the ants grow. So it’s a cool … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… into their work on all kinds of organisms, from plants and fungi to microbes and viruses. Listen in to explore the data …

… genome sequencing of new fungal species.  Students collect fungi, sterilize tissue, isolate genes and more. The metadata then goes into iNaturalist. … 300+ students 800+ iNaturalist observations All MycoEd protocols, course materials and bioinformatics exercises are …

… networking, because I really enjoyed the review that you wrote with Marnix on putting that stuff together. It’s been … in the terms biosynthetic gene clusters and genome size. And they’re so complex. There’s so much still to … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… improved annotation and functional prediction for phage proteins user-friendly integrated pipelines (MVP) and …

… It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … media. So you could take International Streptomyces Protocol media number 2, ISP2, and dilute it by a factor of … 20 analogs at this point. And Casey and Nikolaou synthesized the everninomicin at Scripps, I guess, 22 years ago. …

… biology of these compounds. And they saw the tree, and I explained to them how I would interpret it. And then he’s … have, right? He was looking for a postdoc and just wrote an email to everyone. And I’m like, oh, I’m looking for … a marine actinomycete bacterium. So they look kind of like fungi but also make these mycelia. They kind of look like …

… products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of … experimental samples, including organisms (e.g. microbes, fungi, plant), media in which they grow, as well as …

… Sure. Definitely. So, I got my PhD with Paul Hergenrother at the University of Illinois at Urbana-Champaign. … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … can activate these, utilizing some of these already synthesized molecules. DAN: OK. These receptors are coming from …

… natural chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your … ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into secondary … actually a very large molecule. Very complicated to synthesize. And so synthesis wasn’t really possible. Eventually, …

… giant viruses, which possess genomes and particle sizes that rival those of cellular organisms. Giant viruses … complexity, and encode for a treasure trove full of novel genes ready to be tapped for downstream applications. … threats in environmental samples. This work combines third generation sequencing and machine learning to enable fast, …