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… part of CRISPR-Cas9 technology to enable improvements in microbial oil production. The Science CRISPR-Cas9 is a … Cas9 needs guide RNA to lead it to the correct sequence to snip — but not all guides are effective. To … approach: CRISPR-Cas9 relies on RNA with a short guiding sequence (20 bp) that directs the endonuclease where to cut, …

CheckV can help researchers assess virus sequence fragments and data quality. The Science Through advances in sequencing technologies and computational approaches, … of metagenome-assembled viral genomes . The Impact The microbes that play key roles in cycling nutrients such as …

…   Visualizing a novel, candidate viral genome found in the deep … ecosystem. The Science Altiarchaea are carbon-fixing microbes and targets of multiple viruses in Earth’s deep … at virus infections. Their genomes include short DNA sequences that code for CRISPR systems, which help bacteria …

… for multiple applications.       Despite advances in sequencing technologies and computational methods in the … small fraction of Earth’s microbial diversity. Because most microbes cannot be cultivated under laboratory conditions, their genomes can’t be sequenced using traditional approaches. Identifying and …

…   To understand virus-host dynamics, computation helps fill in what cultivation can’t. The Science At first, viruses are … to commandeer. For bacteriophage viruses, these hosts are microbes like bacteria, not humans. With metagenomic … kinds of ecosystems. However, matching these viral genetic sequences to their hosts is crucial to understanding what …