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How to Target a Microbial Needle within a Community Haystack
… targeted genomic approach would allow researchers to focus on specific microbes within metagenome samples and … (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Lawrence Berkeley National … , combines multiple techniques and was demonstrated using a specific group of marine bacteria called “Vis6” that …
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Tuning fresh: radiation through rewiring of central metabolism in streamlined bacteria
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Tuning of Gene Expression in Clostridium phytofermentans Using Synthetic Promoters and CRISPRi
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Here, There and Everywhere: Large and Giant Viruses Abound Globally
… expands the global diversity of large and giant viruses. While the microbes in a single drop of water could outnumber a small city’s population, the number of viruses in the same drop—the vast majority not harmful to … associated with viruses, while the genomes of large viruses may be only 10 times larger. And yet, while they are found …
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Ancient Algae Reveal Secrets of Plant Evolution
… to terrestrial life paves the way for innovations in sustainable agriculture and clean energy. These evolutionary … in marginal lands and with minimal resources. Enabling the use of non-arable land for biomass production — that can be … for three strains of  Zygnema circumcarinatum . Published  May 2024 in  Nature Genetics by an international research …
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An Automated Tool for Assessing Virus Data Quality
… CheckV can help researchers assess virus sequence fragments and data quality. The Science Through … technologies and computational approaches, more and more virus sequences are being recovered and identified from … that have integrated into the host genome, these sequences may be tainted by the presence of non-viral genes. Up to …
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GenomeOcean Leverages AI to Decode Nature’s Secret Language
… now available to the global research community able to not just analyze but also create DNA sequences mimicking an array of microbial life. By leveraging massive user-generated datasets at the JGI and other publicly … researchers in order to enhance what it can offer. As of June 2025, Genome Ocean was ranked the No. 1 most-downloaded …
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How Maize Makes An Antibiotic Cocktail
… a family of compounds that protects it against infections — using surprisingly few enzymes. The Science Maize ( Zea mays ) produces a plethora of antibiotics called zealexins. … scientists have identified at least 15 zealexins, they suspect there are even more to find. Zealexins are produced …
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JGI@25: Fueling Investigation into Methane-Making Microbes
… down potential biomass sources in ways we are only just beginning to understand. A better understanding of rumen … inhibit microbial methane production. Another effort is in using microbial understanding to formulate a vaccine for livestock, to the same effect. Yet another approach is using the Hungate1000 collection to identify microbial …
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Corymbia Genome Expands Terpene Synthesis Knowledge
… lineages. The Science From the distinct smell of eucalyptus to the flavor of wine, terpenes are ubiquitous. A diverse group of plant-produced organic compounds, … of the evolution and selection of this gene family may help researchers manipulate TPS genes to increase …
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JGI Early Career Researchers Featured in mSystems Special Issue
… In a special issue of mSystems , out May 14, 2019, JGI researchers are among the authors who … method of traditional shotgun metagenomics. One approach uses fluorescence-activated cell sorting (FACS) to sort … a recent Nature Communications paper, uncovering giant virus sequences in soil for the first time. A second approach …
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Meeting Report: “Metagenomics, Metadata and Meta-analysis” (M3) Workshop at the Pacific Symposium on Biocomputing 2010
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