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… further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not … has historically been limited due to the lack of robust tools available for carrying CRISPR into microorganisms. … As a demonstration, the researchers used CRAGE-CRISPR for discovering active secondary metabolites and helping them …

… Describing the largest analysis to date of the modified DNA base 5mC variations in fungi. The … the largest analysis of 5mC distribution across the fungal tree of life to date, involving more than 500 species of fungi. The … The work conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science …

… Undergraduate Research Experience (CURE) that consists of coordinated hands-on experiments across fungal biology teaching labs. The purpose of the program is to: train students and professors in laboratory techniques and data analyses compile … Beyond providing a scalable solution for production of high-quality fungal reference genomes, this program is an …

… the JGI in 2017 to lead viral genomics research as part of the Metagenome Program. His responsibilities include the development of novel computational tools to identify virus sequences, the design of new … knowledge of viral diversity and virus-host interactions in microbial systems. Through a 2021 DOE Early Career Research …

… Institute.  The Science Researchers report the discovery of miniature Clustered Regularly Interspaced Short … was made possible by mining the datasets in the Integrated Microbial Genomes and Microbiomes (IMG/M) suite of tools managed by the U.S. Department of Energy (DOE) Joint …

… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our collaborations and … with the poplar, a JGI Flagship Genome and the first tree to have its genome sequenced. Having this first genome … Genome Inside: THE Bioenergy Tree …

… The JGI was honored to host some of the brightest minds in genetics as part of our  2022 … audience down memory lane, recounting the earliest days of discovering CRISPR-Cas9, the powerful gene editing … applications like overcoming antibiotic resistance and discovering new ways to combat disease. In speaking more …