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The Science CRISPR-Cas9 is a powerful, high-throughput gene-editing tool that can help scientists engineer … to snip — but not all guides are effective. To ensure the gene editing tool will make the right cut, researchers … these sgRNAs, cloning them alongside CRISPR-Cas9 into an expression vector to create an sgRNA plasmid library. The …

Fashioning DNA outside a cell is key to interrogating what genes do, how they work, and applying them to environmental … terpenes, the JGI synthesized several of the underlying genes. These genes then provided a foundation that allowed … in the Synthetic Biology special issue, Modular cell-free expression plasmids to accelerate biological design in cells …

… the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …

… project to form new connections between fungal guilds, genes and function. If a tree falls in the forest — whether … in four forest ecosystems, extracted RNA to understand gene expression, and developed new tools to map that soil …

The Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a … functional assay lets us move beyond cataloging the genes of microorganisms and start making quantitative …

A genetic architecture that is characteristic of the sex … to analyze their structure. Scientists found both a gene likely important for sex determination and a shared … gene conversion in willow. This gene regulates the expression of other genes in response to cytokinin, a key …

… a quest to better understand the factors and mechanics of gene expression in over 400 fungi species. “Fungi are the masters … “survival of the fittest” theory — the most expressed genes found across each of the fungal species were …

… access and analyze data on scales ranging from single genes and individual genomes to metagenomes to systems-level …

… the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …