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… chemical factories. They hold genetic blueprints for dozens of complex compounds, but stay largely dormant under … Summary Most Streptomyces species can produce roughly 30 secondary metabolites — chemical compounds not required for basic … This work conducted by the U.S. Department of Energy Joint Genome Institute …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … Successful applications will focus on high-risk/high-payoff proposals within the focused topic areas that can be … CSP projects. In addition, they must utilize a broad range of the capabilities across at least two of the facilities, …

… A preview of how large-scale single cell genomics complements … studies. The Science Researchers demonstrated the value of conducting large-scale single cell genomics by collecting … Such techniques take advantage of bioinformatics tools for  extracting snippets of microbial genomes directly from …

… JGI’s  MycoCosm data portal , an interactive collection of sequenced fungal genomes, omics data and comparative … asked and whether they are within DOE mission areas of bioenergy, carbon cycling, and biogeochemistry. This is a … and TCDB ( http://tcdb.org/ ) databases, respectively. For secondary metabolism clusters, we have developed in-house …

… The JGI was honored to host some of the brightest minds in genetics as part of our  2022 Annual Meeting . The meeting was a hybrid … form these blooms, all the way to individual cells, and the metabolites, vesicles, and virions they produce. To … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …

… Leveraging decades of technological development, dozens of reference genomes and thousands of resequenced sorghum varieties, a resource for breeders … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility  located at Lawrence …

… from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for understanding the microbiome of the earth, but most species do not grow easily in the … sequencing and single-cell sequencing. For years, extracting single cells and then amplifying their DNA for …

… The Science Researchers have successfully automated aspects of a commonly-used process for studying microbial … with results published in the  November 2022 issue of Microbiome . High-throughput stable isotope probing (SIP) … up the pace at which researchers can extract the bioenergy secrets they hold. HT-SIP is a capability available to …

… The work was enabled in part by a community data portal of the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office … have begun the complex process of uncovering the hidden secrets of soil viruses. The Impact The specific protein … This work was supported by the Department of Energy (DOE) Office of Biological and Environmental …

… been utilizing metagenomics as a way to study a collection of hard-to-culture microbes, but the efficacy of this approach would be greatly increased by having the … JGI User Programs Deputy Susannah Tringe , suggest that extracting high-quality genomes from soil metagenome data is …

… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of notable achievements that showcase our collaborations and … sorghum’s hardiness, so understanding sorghum’s survival secrets could change not only how we use and grow sorghum, …

… efforts to expand the metabolomics capabilities and product offerings for JGI users.  Using cutting-edge mass … techniques, the platform delivers rich metabolite profiles from diverse biological and environmental samples in support of user science.  Capabilities offered by the platform are a …