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… Brad: Yeah, for sure. So we’re going back to the mid-late ’80s. And at that time, you know, it’s before genomics … synthesis, the area of discovery, was just budding in the 80s. So that was pretty special. And for someone like …

… learn as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. Methylotroph … by Inverse Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… Amplification (PTA) yields a much higher completion, above 80% in most cases. The Impact PTA is a refined capability … like plasmids, the picture is far from complete.  In 2021 , scientists at St. Jude Children’s Research Hospital … genomes from water and soil communities were at least 80% complete when studied with PTA, compared to <30% …