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… in the old days, saw how hard it was – it felt kind of like training for a marathon by running at a high altitude! … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

Software engineers in the Synthetic Biology Informatics Group … tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination and Golden Gate methods SynTrack and …

Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a genome miner and has been involved with the … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

Our research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … him. And I said, you know, I’m here to find a job. I would like to do something completely new. And that is to begin to … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… from the Great Salt Lake, and you’re going to learn, like me, what a “haboob” is. Then, we switch interview … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… or reaching out on Twitter to @JGI or me @danudwary. Like I said in the intro to the first episode , after this … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

The JGI has diverse capabilities in: DNA and RNA sequencing, Sample … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

… about natural products you’ll get a good sense of what it’s like working with him.  We talk about his father, the … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

Below is a brief description of the process needed to prepare and ship samples for sequencing by the JGI. … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… and scientific research, especially at US National Labs, like Lawrence Berkeley Lab (that’s LBL), the National Lab … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM database … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …