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… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … resources, but they don’t necessarily have the support network, the equipment, the facilities to really apply the … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… Not one of our normal interviews, but instead it’s two interviews in one. My new co-host, Jackie Winter, has … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … better to do it together, to join forces instead of to make two competing tools. If we had known about your tool, Dan, …

… in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … necessary to extract meaningful biological insights from sequence data, employing IMG data and tools for comparative …

… be proposing a larger project that requires the work of two or more DOE user science facilities. That’s kind of out … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… out, you probably want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… information sharing. We also recognize the need to have a limited and time-sensitive protection of certain types of data … For DNA synthesis projects: data are subject to a  two-year embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… so they’re secondary metabolite peptides. And there are two ways that nature does this. The more well-known … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… at the University of Illinois at Urbana-Champaign. I had a two body problem, and it was a really great opportunity to … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …