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… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … it’s very situational. And every microbe is a special snowflake. So… ALISON: Yeah, I mean, would you say that all …

… by exploring plants’ role in capturing carbon, detoxifying soils, interacting with other organisms, and adapting to … of how plants have naturally adapted to varied climate and soil conditions around the globe to identify genes to … manipulation in the laboratory. Both germplasm (sequenced mutants and natural accessions) and protocols …

… pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … NARAYAN: I like to think every enzyme is a little snowflake. JACKIE WINTER: To treat it so it’s a delicate … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… they grow, as well as different types of environments (e.g. soil, lake).  A wide range of metabolites are identified using …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … think the terms we should be using for what we do are, and why there and why it’s important to make those distinctions. … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… distribution of microbial genome and microbiome datasets sequenced at the JGI. IMG/M is also open to scientists …

… the program supports foundational research related to soil nutrient cycling and health, terrestrial biogeochemical … samples — including microbes, fungi, plants and soils. Through a combination of experimental workflows and … the interactions between  plants, microbes, and soils relevant to key environmental processes and the …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … I’ve seen you give a few talks on that. Can you tell us why cone snails are so cool? ERIC:  So cone snails are … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … off through these areas. And you can do– with a teaspoon of soil from outside, you maybe have to do a 10,000-fold …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … is a chemical compound called geosmin that’s produced by soil bacteria that live all over the place. So that smell of …