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… that we are not finding. We are going to have more resistant bacteria. There are lots of resistant bacteria out … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … just from the biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … reopen the book and come up with antibiotics for multidrug-resistant infections and that kind of thing. So we’re still …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … half or more require salt. So how do you define a marine bacterium? I think you define it by perhaps having a salt … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… … Adaptive strategies in a cosmopolitan and abundant soil bacterium: genetic microdiversity or core metabolic …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … in your book you mentioned working on several antibiotic resistant microbes including a bacterium called … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … Institute interested in a marine obligate actinomycete bacterium called Salinospora . This new genus was discovered … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … or you know, you’ve run into challenges that demonstrate why this is so important. BEN:  Yeah. So I wouldn’t call it …