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… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language of microbial cell-cell communication. And he told us about his … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … genetic elements. Beyond exploring and characterizing microbial diversity, work in the Metagenome Program uses several experimental approaches to assess microbial activity across ecosystems.  By studying microbial …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties … within those genomes. Our aim is to more fully capture microbial and viral diversity, leading to a better …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … that we found, indeed, that both formulations had some antimicrobial properties. But the one that was used in …

… Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of the product and … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is … in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called …

… See below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, as well as successful submissions to our CSP New Investigator, CSP Functional Genomics, and Facilities … Microbial contributions to soil carbon storage during …