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… use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And they have all … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… activity. So the chemistry and function really of those microbes that live there.  And in our work we’ve determined … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, … techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … The Microbial Program focuses on using advanced sequencing technologies to explore microbial …

… Hey everyone. Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… Research in the Eloe-Fadrosh group focuses on using genome-resolved metagenomic approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … where smaller proposals may be a fit. Still not 20 many microbes. We still we work in plates, right? We’re a high … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … The Metagenome Program focuses on the high-throughput sequencing of … Exploration of phylogenomic novelty: Advances in metagenomic sequencing, assembly and binning have enabled …

… The mission of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve … The researcher then submits a proposal for consideration in the next … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …