Search

… through isolation and genome sequencing of new fungal species.  Students collect fungi, sterilize tissue, isolate … and distribution of fungal genome datasets. It includes JGI-sequenced and publicly available datasets encompassing a … and researchers, facilitating the transition from genomic sequences to biological inference and understanding of …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … one of the most common animals in the ocean. They’re really species-diverse. I lost track actually of the number. But, … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… aflatoxin being a secondary metabolite from an Aspergillus species that is pretty toxic – can cause liver cancer and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… and environmental sustainability. Fungi, with million species, are essential for ecosystem functioning — … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of … of fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and …

… embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … able to produce chemistry that deals with reactive oxygen species and so potentially could go down that route.  DAN: … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … family would be a set of gene clusters across different species, which all encode the production of either the same …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … are novel. I mean, we have Streptomyces , but they’re new species. And they have very similar [genomes] to other …