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… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … a mixture of, for example, metatranscriptome sequencing, metagenomics, single cell genomics. We even do the flow … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast … The Microbial Program focuses on using advanced sequencing technologies to explore microbial diversity — with an … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from …

… for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… (a marmot!) as they’ve sampled the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains. These lakes are … They’re a great way to see how climate change affects freshwater ecosystems, and how those ecosystems work. …

… The mission of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most relevant bioenergy … The researcher then submits a proposal for consideration in the next review cycle. All proposals undergo technical …

… Hey everyone. Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… the genetic makeup of natural microbial communities using a variety of cutting-edge approaches.  Our group also seeks out new … that utilize microfluidics/microdroplet technology in order to enhance the quality of single-cell genomes and … offers the first quantitative Stable Isotope Probing (SIP) Metagenomics pipeline that utilizes internal analytical …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it going?  DAN: Good. How are you?  MARCY: Am fine. I live in a … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …