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… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … primer episode, we talked about genome mining through some metagenome associated genomes. And yes, antiSMASH is …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … and archaeal genomes that were created – these are Metagenome Associated Genomes, or MAGs. So these are genomes …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … for you, we sequenced thousands for you or thousands metagenomes. And I think also the quality that we provide. … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… schedule. This should be coming out on the first Thursday of the month, just like I promised. Now I just have to make … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … step for many projects at the JGI. The quality of the starting material is one of the greatest predictors …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we think about enzyme function is we think about the natural function versus can … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the biological … into practical applications, including sustainable biofuels, biomaterials, natural products, and environmental …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … by bacterial or fungal metabolism by microbes, will have a functional role. We started from that. Evolution doesn’t … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national … at Lawrence Berkeley National Laboratory. The JGI consists of 225 researchers and support staff in the Integrative … to large-scale datasets and analysis tools for genomes, metagenomes, and metabolomics through its data portals. …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … and are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … the end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted at environmental … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …