Search

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … the community so far. But being here and then being at the Marine Natural Products meeting in Ventura where I got to …

… scientific discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  The DOE … The ranked proposal list, along with a recommendation from management at JGI and the other participating … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … has to have a story. And it can be looking for drugs from marine organisms, in which case you get to go to exotic …

… in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … of organics will not be considered. Projects targeting marine systems must clearly demonstrate relevance and … heavy metals or radionuclides in soils, freshwater, coastal sediments (coastal here defined  by NOAA as the area within …

This time, we’ve got a great interview with Ben Shen, from the Scripps Research Institute in Jupiter Florida. This … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … just not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… product dioxin ubiquinone, which actually comes from a marine bacterium. And so, I was working on chemically … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

DAN: Welcome back to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … areas that are less of a focus, I would say. For example, marine research is not so much of a focus within BER … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … tools that enhance biofuel production and biosystem design. High-throughput design and synthesis capabilities accelerate …