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… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … So there’s a lot of– we also have a lot of analysis pipelines, be it for, again, metagenome, metatranscriptomes for … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… polymer structure has specific preferences to cancer cell lines. So, that was introduced in Japan as a very first … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… genomic resources that fostered the widespread adoption of Brachypodium distachyon as an experimental model for the … partners, generated hundreds of transgenic switchgrass lines in an effort to create improved varieties for biomass … on developing plant functional genomic resources (e.g. sequenced mutant collections, transformation technology, …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … metabolites evolve– who makes them, how do they spread, why do they spread in a certain way from one bacteria to … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … I think that a secondary metabolism as a field, or subdisciplines, started to grow and have different perspectives– from … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … tool for generating synthetic sequencing data from genomic sequences … A predictive tool for microbial symbionts in environmental sequence data, including microbial phenotype along the …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … it allows us to assay on a single cell level against cell lines and against primary cells isolated from patients up to …

… computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, … The SMC provides complete sequence and annotation data for secondary metabolite … and the public, and provide programmatic access to all sequence and annotation data and their comments. …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … Institute who had a panel of 60 different cancer cell lines. And we would send them these compounds. We would test … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … between chemistry and sequence to get anywhere. Like that’s why I say the more you know, the more you know because it …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … So I could focus on those without looming board deadlines. ALISON: Yeah, it sounds like a good choice if the …