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The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural … searches to expand representation of uncultivated microbial lineages. Charting viral ‘dark matter’:   Viruses are … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… capabilities, large-scale data and professional expertise to support the global research community in studies of … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … must clearly demonstrate relevance and translatability to freshwater, coastal or terrestrial systems. Additional …

So we do a couple of different things. Most of them are actinobacteria. And so we get a lot of them from databases … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… of Energy (DOE) Joint Genome Institute (JGI) are subject to the following Data Policy. It is our mission to support … and later through the Community Science Program (CSP), Facilities Integrating Collaborations for User Science … embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA synthesis requests, the … below these thresholds, you will need to utilize a core facility instead. Proposals may not exceed 10 Tbp sequencing, …

… (DOE) Joint Genome Institute (JGI) is a national user facility located at Lawrence Berkeley National Laboratory. The JGI consists of around 280 researchers and support …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … take one of those and co-culture them with say one of our Actinobacteria what will happen? Will it create chemistry …

… … DAN UDWARY: Hey everyone. Welcome back to Natural Prodcast. This continues the series of interviews … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… … Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … are marine related, and so we can do some projects that are freshwater and coastal. But we’ve kind of shied away from …

The mission of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …