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… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … has eight chromosomes. It goes by genera. Neurospora has four chromosomes. So if you have one of these fungi, can you …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … in our bedroom together with us still while she’s still four months old. So it’s not a bad location for a little … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … then we would take our two foot core. And so that’s only four feet in. And there is quite a bit of sun and exposure … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … they were expecting to. So you might know of like three or four or five molecules that you maybe had found and ground …

… through isolation and genome sequencing of new fungal species.  Students collect fungi, sterilize tissue, isolate … and distribution of fungal genome datasets. It includes JGI-sequenced and publicly available datasets encompassing a … and researchers, facilitating the transition from genomic sequences to biological inference and understanding of …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we …

… food and health and botanical medicine. I’m also a mom of four kids now so ranging from 8 to 17 in age, so my home … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … really what my research focus has been. Maybe the last four or five years or so, this involves, you know, how …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … one of the most common animals in the ocean. They’re really species-diverse. I lost track actually of the number. But, … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …