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… and delays on the work. The transfer of a proposal from one commercial institution to a new commercial … requirements as other academic lead institutions. OTHER DOE NATIONAL LABORATORIES:  A version of the Bilateral DOE … Before work can begin on proposals submitted by researchers from another DOE National Laboratory, a JGI-BDLUA ,  BDLUA …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties … within those genomes. Our aim is to more fully capture microbial and viral diversity, leading to a better …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… maybe it’s a new culture of a new bacteria that you pulled from the soil, maybe it’s, you know, we talked about … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… As a National User Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … Our metabolomics platform delivers rich metabolite profiles from diverse biological and environmental samples by using …

… to request the capabilities and expertise of both national user facilities in one research proposal.  Submit … and shipping; JGI will handle all subsequent processing from that point. JGI provides users with various outputs … publicly available. If you're requesting DNA synthesis from JGI, there's also a material transfer agreement that’s …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … isn’t true of all of them, but for certain types, they’re extremely repetitive. And what that means when you’re trying …

… prefers to be known among friends in natural products. He’s from Langebio in Irapuato, Mexico, and an incredibly bright … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in cave microbial– people are interested in the more extreme portions of caves where you have to go miles …

… which is a great website name, and also extremely well-organized, makes doing research on a person … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… applied to samples collected from acidic iron-oxide microbial mats in Yellowstone National Park over time, … thousands to millions of copies of a particular DNA sequence from just a few pieces of DNA. Summary The extreme environments found in Yellowstone National Park …

… The CSP and FICUS calls are open to both domestic and international applicants from any institution type and at any career stage. … users are able to work with Berkeley Lab.  However, users from certain countries (Iran, North Korea, Cuba, and Syria), … The deliverables can range from raw sequence data to well-annotated assembled genomes to …