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… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… maybe it’s a new culture of a new bacteria that you pulled from the soil, maybe it’s, you know, we talked about … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

The CSP and FICUS calls are open to both domestic and international applicants from any institution type and at any career stage. … for advice!      … The deliverables can range from raw sequence data to well-annotated assembled genomes to …

… of Energy (DOE) Joint Genome Institute (JGI) is a national user facility located at Lawrence Berkeley National Laboratory. The JGI consists of around 280 … such as the DOE Systems Biology Knowledgebase and the National Microbiome Data Collective.        … Learn more …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the … UGA-Langebio in Irapuato, Mexico. His interests are in microbial diversity and evolution, particularly as how …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … isn’t true of all of them, but for certain types, they’re extremely repetitive. And what that means when you’re trying …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in cave microbial– people are interested in the more extreme portions of caves where you have to go miles …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of … Institute (JGI) ( https://ror.org/04xm1d337 ) and the National Energy Research Scientific Computing Center (NERSC) …

… which is a great website name, and also extremely well-organized, makes doing research on a person … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … took a long time for .. I mean, structural elucidation was extremely difficult before the advent of two dimensional NMR … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …