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… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … known to be symbionts of things like invertebrates like mussels. DAN: Oh, OK. Cool. Very cool. JACKIE: Yeah, very …

… neither the United States Government nor the University of California nor any of their employees, makes any warranty, … by the United States Government or the University of California. The views and opinions of authors expressed … those of the United States Government or the University of California, and shall not be used for advertising or product …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … metabolites evolve– who makes them, how do they spread, why do they spread in a certain way from one bacteria to … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … think the terms we should be using for what we do are, and why there and why it’s important to make those distinctions. … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … tool for generating synthetic sequencing data from genomic sequences … A predictive tool for microbial symbionts in environmental sequence data, including microbial phenotype along the …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … or you know, you’ve run into challenges that demonstrate why this is so important. BEN:  Yeah. So I wouldn’t call it …

… solve energy and environmental challenges.   Scanning the California oak woodlands from the air, large swaths of the … has served as just that on a catastrophic scale from Baja California north into Oregon and beyond. The disease is … of millions of trees in California alone. With the genome sequence in hand, the UC team led the charge to develop …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … of the fun things that I hope that I can express today is why secondary metabolism is interesting and why it is that …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … section. We want to be sure that the PIs can articulate why their work falls within one of these DOE mission areas. …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… University of California, Merced …