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… … DAN UDWARY: Hey everyone. Welcome back to Natural Prodcast. … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

The Mycological Curriculum for Education and Discovery  (Myco-Ed) is a … through isolation and genome sequencing of new fungal species.  Students collect fungi, sterilize tissue, isolate … and distribution of fungal genome datasets. It includes JGI-sequenced and publicly available datasets encompassing a …

… … DAN: You’re listening to the US Department of Energy Joint … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we …

… … DAN: You’re listening to the US Department of Energy Joint … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… … DAN: You’re listening to the US Department of Energy Joint … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

The Fungal & Algal Program explores the vast diversity of fungi and … and environmental sustainability. Fungi, with million species, are essential for ecosystem functioning — … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

Data produced and released by the US Department of Energy (DOE) Joint … embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… … DAN: Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… … Dan Udwary: You’re listening to the Department of Energy … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …