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… our interview this week is with Professor Brian Bachmann from Vanderbilt University’s Chemistry Department, where he … which includes screening methods, genome mining in cave microbiomes, and using engineered biosynthetic pathways and … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … on Aflatoxin biosynthesis while he was a postdoc in Craig Townsend’s lab at Johns Hopkins, where I was a … our specialty. That’s where most diversity of life on earth is located. ALISON:  Have you been continuing the …

… we get to present our conversation with Marnix Medema , from Wageningen University in the Netherlands. Marnix is … and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

DAN: Welcome back to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting … they deserve. They are so exciting. I get frustrated. Like microbiomes  – you know how that’s a big deal now. You go to …   DAN: Got it.    NANCY: And this is really to complete the genomes, and I’m really thankful for this. It sort of goes …

Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … in graduate school. I joined the lab of Professor Craig Townsend at Johns Hopkins University. He does … a picture in your head. It’s a warm summer day, it’s been dry for a while maybe it hasn’t rained in a while. Picture …

… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … slides that float around here, there is a term called “Earth’s Secondary Metabolome.” Do you want to explain to … secondary metabolism analysis and research as a driver for novel technologies that can serve all JGI users. Nigel has a …

… the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of marine … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola . … had experienced the largest bloom ever observed on planet Earth. This was the 2015 Pseudonichia diatom bloom. It made …

… where, among lots of other things, he works on the Tiny Earth project, which you’ll hear him describe. [ Go here to … in the project by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] … the secondary metabolism side of things was looking at genomes and seeing where the really hard things to sequence …

… is really another example. This sort of carbon arrangement, which we know as a structure of a natural product, … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… the product and deliverables as well as target cycle times from sample receipt to completion of standard analysis.  Raw … and quality of finished product depend on genome. Selected genomes will be improved based on feasibility and scientific … Fungal Resequencing SNP and short indel calls, rearrangement detection, population analysis Text file of SNPs …

Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and … in collaboration with other people, lake sediments. We have microbiomes from different organisms, including the human …