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… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … to learn more about JGI, hear some excellent talk from our users and from other invited guests, and we’ll also … slides that float around here, there is a term called “Earth’s Secondary Metabolome.” Do you want to explain to …

… we get to present our conversation with Marnix Medema , from Wageningen University in the Netherlands. Marnix is … and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s been … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and … in collaboration with other people, lake sediments. We have microbiomes from different organisms, including the human …

… agricultural productivity. Research spans diverse areas — from understanding how terrestrial plants and phytoplankton … capture atmospheric carbon, helping to regulate Earth's carbon balance, to exploring the genetic basis of … Plant Flagship Genomes are selected through discussion with the JGI Plant …

… our interview this week is with Professor Brian Bachmann from Vanderbilt University’s Chemistry Department, where he … which includes screening methods, genome mining in cave microbiomes, and using engineered biosynthetic pathways and … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… is really another example. This sort of carbon arrangement, which we know as a structure of a natural product, … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly …

… the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of marine … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola . … had experienced the largest bloom ever observed on planet Earth. This was the 2015 Pseudonichia diatom bloom. It made …

… The guest we have this week is Professor Cassandra Quave from Emory University, with joint appointments in the School … use successfully, hopefully, in the future even more so as novel therapies. And that’s how I got on that path of … it’s not that easy. There are still not that many plant genomes, certainly nowhere close to bacterial kinds of …

… studied chemistry, because she switched her degree program from geography to chemistry. So we were both enrolled as … currently exist. We looked at chemistry, so it’s really novel. And they’re just really exciting. And it really kind … there have been huge advances in both. The cool thing about genomes is you can, well, if your assembly is good, you can …

… almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we … We find chemistry that’s known, or sometimes novel, but often known, and yet the clusters don’t look the … a project that’s looked at ants and their symbiotic arrangement with a fungus and bacteria that protect the fungus. …