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… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s been … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… where, among lots of other things, he works on the Tiny Earth project, which you’ll hear him describe. [ Go here to … in the project by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] … the secondary metabolism side of things was looking at genomes and seeing where the really hard things to sequence …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … of Life. We then investigate the coding potential to find novel functions that may impact microbiome structure and …

… our interview this week is with Professor Brian Bachmann from Vanderbilt University’s Chemistry Department, where he … which includes screening methods, genome mining in cave microbiomes, and using engineered biosynthetic pathways and … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… is really another example. This sort of carbon arrangement, which we know as a structure of a natural product, … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly …

… agricultural productivity. Research spans diverse areas — from understanding how terrestrial plants and phytoplankton … and environmental sustainability. … Plant Flagship Genomes are selected through discussion with the JGI Plant … relationships as well as insights into clade-specific novelties and expansions.  … Brachypodium distachyon is an …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … it turns out that a lot of natural products are built up from amino acids, so they’re secondary metabolite peptides. … our specialty. That’s where most diversity of life on earth is located. ALISON:  Have you been continuing the …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of marine … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola . … had experienced the largest bloom ever observed on planet Earth. This was the 2015 Pseudonichia diatom bloom. It made …

… and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the … direct applications in bioenergy production, carbon management, and environmental sustainability. Fungi, with … is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of Life, from an international …

DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire … analysis and annotation of all publicly available genomes from three domains of life, in a uniquely integrated … relationships as well as insights into clade-specific novelties and expansions.  … ICE is an open source registry …

… almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we … We find chemistry that’s known, or sometimes novel, but often known, and yet the clusters don’t look the … a project that’s looked at ants and their symbiotic arrangement with a fungus and bacteria that protect the fungus. …