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… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … many different avenues toward chemistry. But that’s kind of where I had you. How would you describe what your … so they end up probably over time dispersing across the chromosome. So I think that’s my feeling.  And so it could …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … cluster database, and a tool for predicting natural product structures from genomes. And I was writing grants furiously … pathway even if the genes are scrambled or altered in the chromosome. And so it becomes very difficult then to compare …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … So he could see really into this– so he could look into the structure, really seeing that. And I’m always just looking … pathways and what’s happening there. And he really saw this structure and how that would make the compound faster or …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … you’re trying to dive and that sort of thing. So it’s not unsurprising this took a while for things to happen. You know, … everybody else started looking at things and doing chemical structures, learning a little bit about things. And that was …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national … at Lawrence Berkeley National Laboratory. The JGI consists of 225 researchers and support staff in the Integrative … The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the science and scientists of secondary metabolism.  DAN: Hey there and welcome back for Episode 8 of Natural Prodcast. This week, we have our conversation …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … that you need to do these coordination bonds, then many structures will be able to work. So, for example, in that … this group of Streptomyces share this. And it will be very surprising to you, Dan, to realize that some of that shared …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … of natural products from invertebrates, mostly. Dan Udwary: Structure elucidation, yeah. Kate Duncan: Right, yeah, so … really cool and really exciting. But what’s sometimes surprising for people is, like I said at the beginning, even …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … “tail of the acyl homoserine lactone” can have different structures, and that is akin to what you’re referring to … a synthase and a transcription factor receptor. And it’s surprising even though the first signal was characterized I …

… Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned …