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… they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … And she happened to work with nature products from cyanobacteria. So that’s how I started. I love the lab, I love … the microviridins. These are cyclic peptides from cyanobacteria. They have a tricyclic structure that’s really …

… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … for amplifying genes. I wasn’t really sure what actinobacteria were. Dan Udwary: Yeah, this all sounds very … them. But fundamental is the chemistry produced by actinobacteria and what influences that. Dan Udwary: I want to …

… years, has been to bring generalizable technologies to bacteria, yeasts and algae previously with little to no …

… in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their …

… particularly sigma factors that initiate transcription in bacteria. Using this technology, which combines an in vitro … expand the known transcriptional regulatory network in bacteria, enabling the discovery of regulatory cascades as … eukaryotes is handled by three distinct RNA polymerases; in bacteria there is only one type of RNA polymerase …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … products and got really interested in thinking about how bacteria actually are able to make some of these really … Yes. JACKIE: And using these hormones as a way that bacteria can talk to each other and then up-regulate or …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … part– which we don’t call it duplication, because in bacteria, I will say it, but I don’t think duplications take …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … lot of the natural products field is based on, you know, in bacterial investigations. You’ve spent your whole career as … it because of the complexity. They’re more complex than bacteria. Not that bacteria aren’t complex themselves. But a …

… Bacterial enzymes play second fiddle to those from fungi … trees, and microbial activity teems beneath your feet. Both bacteria and fungi have genes that can break down plant … Fungi are much more active in degrading plant matter, and bacteria are more active in fixing and metabolizing …

… delicately above the leaf debris are revealed to be single bacterial cells, visible to the naked eye. The unusual size is notable because bacteria aren’t usually visible without the assistance of microscope. “It’s 5,000 times bigger than most bacteria. To put it into context, it would be like a human …

… a method that allows researchers to quickly modify diverse bacterial genomes. In 2019, the JGI’s Yasuo Yoshikuni and … example, the JGI first used CRAGE to engineer domesticated bacterial strains with novel biosynthetic gene clusters … molecules of value to both human and ecosystem health. But bacteria often fail to express their BGC molecules in the …